Article: Promoter Hypermethylation Profiling Identifies Subtypes of Head and Neck Cancer with Distinct Viral, Environmental, Genetic and Survival Characteristics.
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Choudhury JH; Ghosh SK
PLoS ONE, 2015
10.1371/journal.pone.0129808.t005
Table 5 Characteristics of the two identified clusters using hierarchical cluster analysis of promoter methylation data.
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Characteristics
Cluster 1 (N = 29) (%)
Cluster 2 (N = 42) (%)
P -value
Smoking
Yes
25 (86.2)
26 (61.9)
0.048
No
4 (13.8)
16 (38.1)
Betel quid chewing
Yes
21 (72.4)
26 (61.9)
0.360
No
8 (27.6)
16 (38.1)
Tobacco chewing
Yes
26 (89.7)
27 (64.3)
0.034
No
3 (10.3)
15 (35.7)
GSTM1
Null
24 (82.8)
16 (38.1)
0.002
Present
5 (17.2)
26 (61.9)
GSTT1
Null
11 (37.9)
18 (42.9)
0.474
Present
18 (62.1)
24 (57.1)
CYP1A1 (T3801)
Wild (TT)
9 (31.05)
20(47.6)
Heterozygous (TC)
11 (37.9)
14 (33.3)
0.997
Variant (CC)
9 (31.05)
8 (19.1)
0.371
XRCC1 (Arg399Gln)
Arg/Arg
8 (27.6)
17 (40.4)
Arg/Gln
13 (44.8)
18 (42.9)
0.428
Gln/Gin
8 (27.6)
7 (16.7)
0.169
XRCC2 (Arg188His)
Arg/Arg
15 (51.7)
31 (73.8)
Arg/His
14 (48.3)
11 (26.2)
0.481
His/His
0
0
HPV status
Present
22 (75.9)
15 (35.7)
0.009
Absent
7 (24.1)
27 (64.3)
CIMP status
Positive
27 (93.1)
1 (2.4)
Low
2 (6.9)
28 (66.7)
<0.001
Negative
0
13 (30.9)
<0.001
P trend
<0.001
P -values were adjusted for age, gender, smoking, HPV, betel-quid and tobacco chewing as appropriate
Inferred neuron-electrophysiology data values
Neuron Type
Neuron Description
Ephys Prop
Extracted Value
Standardized Value
Content Source
